Custom Peptides
Cayman Chemical ObtusIfolIn 10mg
An anthraquinone with diverse biological activities; prevents IL-1β-induced increases in NF-κB phosphorylation in chondrocytes at 25-200 µM; reduces cartilage degradation in a mouse model of DMM-induced osteoarthritis at 100 mg/kg; reduces blood glucose levels, as well as serum MDA, NO, triglyceride, and cholesterol levels, and increases serum SOD, GSH, and CAT activity at 30 and 90 mg/kg in a mouse model of STZ-induced diabetes
Cayman Chemical SynthetIc Curzeren 10mg
A sesquiterpene with diverse biological activities; scavenges DPPH radicals in a cell-free assay at 3.36 UG/L with a synergistic effect when used in combination with eucalyptol; active against F. graminearum at 0.5 mg/ml; inhibits the proliferation of SK-MEL-19 melanoma cells (IC50 = 5.17 UG/ml), as well as AGP-01 gastric and HCT116 colon cancer cells (IC50s = 8.04 and 9.18 UG/ml, respectively) and MRC-5 non-cancerous human fibroblasts (IC50 = 11.45 UG/ml); induces apoptosis in, and decreases migration of, SK-MEL-19 cells at 5 and 10 µM; reduces tumor weight in an SPC-A1 mouse xenograft model at 135 mg/kg
Cayman Chemical Bluma balsamfra Blumatn 10mg
A flavonoid with antioxidant and anticancer activities; scavenges DPPH radicals in a cell-free assay (SC50 = 90.8 UG/ml); decreases carbon tetrachloride-induced lipid peroxidation in isolated rhesus monkey hepatocytes; cytotoxic to KB oral carcinoma cells (IC50 = 47.72 UG/ml)
Cayman Chemical Agrmona plosa Agrmol B 10mg
A polyphenol with adipogenesis inhibitory and anticancer activities; induces nuclear translocation of SIRT1 and reduces expression of PPARγ, C/EBPα, and FASN in 3T3-L1 adipocytes at 10 µM; reduces lipid droplet accumulation in 3T3-L1 adipocytes (IC50 = 3.35 µM); cytotoxic to PC3 prostate and A549 lung cancer cells in vitro; reduces tumor volume in a PC3 mouse xenograft model at 10 mg/kg
Cayman Chemical NdSmethyl DIltIazemhydroc 10mg
An active metabolite of diltiazem; binds to isolated rat cerebral cortex homogenates (IC50 = 323 nM); inhibits spontaneous contractions in isolated rat portal veins (IC50 = 489 nM); has been found as a contaminant in fresh water
Cayman Chemical 1MyrIstoyl2LInoleoyl3Ole 10mg
A triacylglycerol; has been found in mature human milk, infant formula fats, and butterfat
Cayman Chemical CyclosporIn C 10mg
A fungal metabolite with diverse biological activities; active against isolates of B. cinerea, A. niger, and Alternaria, Mucor, and Penicillium species (MICs = 0.1-5 μg/ml); inhibits vaccinia virus replication in infected BSC40 cells by 98.82% at 15 μg/ml; inhibits lymphocyte proliferation induced by the mitogens ConA, PHA, and PWM, as well as proliferation induced by alloantigen in mixed lymphocyte at 100 ng/ml; inhibits the local GVH reaction in mice receiving splenocyte grafts at 100 ng/ml
Cayman Chemical 123 TrImyrIstoloyl GlycRo 10mg
A triacylglycerol; has been found in Idiazabal cheese
Cayman Chemical EchInocystIc AcId 10mg
A triterpene with diverse biological activities; induces nuclear translocation of the GR and reduces TNF-α-induced NF-κB signaling in HEK293 cells overexpressing GFP-GR; suppresses RANKL-induced NF-κB activation, ERK phosphorylation, and osteoclastogenesis in mouse BMMs at 12.5, 25, and 50 μM; induces neurite outgrowth in Neuro2A cells; decreases escape latency in the Morris water maze and increases the length of neurite processes in the hippocampus of aged mice at 10 mg/kg per day; topical administration reduces TPA-induced expression of COX-2, iNOS, TNF-α, and IL-1β and EAr edema in a mouse model of dermatitis; recovers reductions in femoral bone mineral density and trabecular thickness and number in a rat model of ovariectomy-induced osteoporosis
Cayman Chemical GInsenosIde Rh1 10mg
A steroid glycoside and saponin with diverse biological activities; inhibits PMA-induced expression of MMP-1, MMP-3, and MMP-9 in U87MG and U373MG human astroglioma cells; inhibits PMA-induced invasion and migration of astroglioma cells in Matrigel™ invasion and wound healing assays, respectively, at 300 μM; inhibits LPS-induced increases in nitrite accumulation, PGE2 synthesis, and iNOS protein levels in RAW 264.7 cells; inhibits histamine release induced by compound 48/80 in rat peritoneal mast cells (IC50 = 37 μM); inhibits IgE-induced passive cutaneous anaphylaxis reactions in mice by 87% at 25 mg/kg, i.p.; a metabolite of ginsenoside Re and ginsenoside Rg1 formed by intestinal microflora
Cayman Chemical NorproprnololhydrochLRIde 10mg
An active metabolite of propranolol; binds to β-ARs (Kd = 42 nM in turkey erythrocytes); inhibits (–)-isoproterenol-induced activation of adenylate cyclase (Ki = 175 nM)
Cayman Chemical 6 8DIfluoro7hydroxy4meth 10mg
A fluorophore; has been conjugated to streptavidin or secondary antibodies for flow cytometry and used to label bacteria for multi-color FISH; has been coupled to peptides to improve electrospray ionization and MS sensitivity in MALDI-TOF MS; displays absorption/emission maxima of 358/455 nm, respectively
Cayman Chemical 1Stearoyl3Oleoylracglyce 10mg
A diacylglycerol; Intermittent fasting decreases skeletal muscle and hepatic levels in NZO mice; concentration decreases from 4.59 to 1.88% during the dry-curing process of Iberian ham
Cayman Chemical Cornus ofcnals Cornusde 10mg
A bisiridoid glycoside with diverse biological activities; induces osteogenic differentiation of isolated human BMSCs at 10, 30, and 60 µM; reduces demyelination, focal inflammation, and Th17 cell spinal cord infiltration, as well as improves neurological deficits in a rat model of EAE at 150 mg/kg; decreases mortality, vascular instability, and pulmonary leukocyte infiltration in a mouse model of cecal ligation and puncture-induced sepsis at 0.4 and 0.8 mg/kg; reduces polydipsia and polyphagia, lowers fasting blood glucose levels, prevents testicular cell apoptosis, and decreases the abundance of Weissella, Clostridium, Anaerotruncus, and Bilophila in the gut microbiome in KK/Ay diabetic mice
Cayman Chemical 2-OL-GalactopyrnosylorI 10mg
A flavonoid glycoside with anti-inflammatory activity; decreases LPS-induced production of NO, IL-6, and TNF-α in RAW 264.7 cells from 100-200 µM